The haplotype of two FSHR polymorphisms in ovarian cancer--a potential role of ethnology in risk modification.

@article{Heubner2009TheHO,
  title={The haplotype of two FSHR polymorphisms in ovarian cancer--a potential role of ethnology in risk modification.},
  author={Martin Leonhard Heubner and Kathrin Riemann and Friedrich Otterbach and Rainer Kimmig and Sabine Kasimir-Bauer and Winfried Siffert and Pauline Wimberger},
  journal={Gynecologic oncology},
  year={2009},
  volume={112 3},
  pages={486-9}
}
OBJECTIVES The precise role of gonadotropins in the carcinogenesis of epithelial ovarian cancer remains uncertain. Recently, the haplotype of two single nucleotide polymorphisms, Thr307Ala (rs6165) and Asn680Ser (rs6166), has been described as a risk factor for ovarian cancer in Chinese women. In this study we investigated the impact of this haplotype regarding the risk to develop ovarian cancer as well as possible effects upon the clinical course in a Caucasian patient sample. SUBJECTS AND… CONTINUE READING

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