The haploinsufficient Col3a1 mouse as a model for vascular Ehlers-Danlos syndrome.

@article{Cooper2010TheHC,
  title={The haploinsufficient Col3a1 mouse as a model for vascular Ehlers-Danlos syndrome.},
  author={Timothy K. Cooper and Qiang Zhong and Melissa Krawczyk and H-J Tae and Gerhard A. M{\"u}ller and Ralf Schubert and Loretha A. Myers and Harry C Dietz and Mark I. Talan and Wilfried Briest},
  journal={Veterinary pathology},
  year={2010},
  volume={47 6},
  pages={
          1028-39
        }
}
Vascular Ehlers-Danlos syndrome is a rare genetic disorder resulting from mutations in the α-1 chain of type III collagen (COL3A1) and manifesting as tissue fragility with spontaneous rupture of the bowel, gravid uterus, or large or medium arteries. The heterozygous Col3a1 knockout mouse was investigated as a model for this disease. The collagen content in the abdominal aorta of heterozygotes was reduced, and functional testing revealed diminishing wall strength of the aorta in these mice… CONTINUE READING

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