The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A inhibit enteric cholinergic transmission in the guinea‐pig ileum

@article{Capasso2006TheHH,
  title={The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A inhibit enteric cholinergic transmission in the guinea‐pig ileum},
  author={Raffaele Capasso and Francesca Borrelli and Francesco Capasso and Daniel J. Siebert and David J. Stewart and Jordan K Zjawiony and Angelo A. Izzo},
  journal={Neurogastroenterology \& Motility},
  year={2006},
  volume={18}
}
Abstract  Salvia divinorum is a widespread hallucinogenic herb traditionally employed for divination, as well as a medicament for several disorders including disturbances of gastrointestinal motility. In the present study we evaluated the effect of a standardized extract from the leaves of S. divinorum (SDE) on enteric cholinergic transmission in the guinea‐pig ileum. SDE reduced electrically evoked contractions without modifying the contractions elicited by exogenous acetylcholine, thus… 
The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation‐induced hypermotility in mice
  • R. Capasso, F. Borrelli, A. Izzo
  • Biology, Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2008
TLDR
It is concluded that salvinorin A may reduce motility through activation of different targets, both in physiological states and during croton oil‐induced intestinal inflammation.
Ultrapotent effects of salvinorin A, a hallucinogenic compound from Salvia divinorum, on LPS-stimulated murine macrophages and its anti-inflammatory action in vivo
TLDR
It is concluded that salvinorin A—via KORs and CB1 receptors—exerts ultrapotent actions on macrophages and also shows moderate antinflammatory effects in vivo.
The antinociceptive effect of salvinorin A in mice.
Neuropharmacology of the Naturally Occurring κ-Opioid Hallucinogen Salvinorin A
TLDR
Salvinorin A has therapeutic potential as a treatment for pain, mood and personality disorders, substance abuse, and gastrointestinal disturbances, and suggests that nonalkaloids are potential scaffolds for drug development for aminergic G-protein coupled receptors.
Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis‐induced hypermotility: cross‐talk between κ‐opioid and cannabinoid CB1 receptors
TLDR
Because intestinal inflammation upregulates cannabinoid receptors and endogenous cannabinoids, the possible involvement of the endogenous cannabinoid system in salvinorin A‐induced delay in motility in the inflamed gut is investigated.
Selective natural kappa opioid and cannabinoid receptor agonists with a potential role in the treatment of gastrointestinal dysfunction.
TLDR
This review summarizes the present knowledge on salvinorin A and its analogues, with a focus on the effects on gastrointestinal tissues, and discusses structural changes in salvin orin A that may facilitate future use of its derivatives in human disease.
Inhibitory effect of the herbal antidepressant St. John’s wort (Hypericum perforatum) on rat gastric motility
TLDR
If extended to humans, the inhibitory effect of SJW extract on gastric emptying in vivo could contribute, at least in part, to the clinical pharmacokinetic interactions between conventional medicines and this herbal antidepressant.
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