The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation‐induced hypermotility in mice

@article{Capasso2008TheHH,
  title={The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation‐induced hypermotility in mice},
  author={Raffaele Capasso and Francesca Borrelli and Jordan K Zjawiony and Lukasz M. Kutrzeba and Gabriella Aviello and Giovanni Sarnelli and Francesco Capasso and Angelo A. Izzo},
  journal={Neurogastroenterology \& Motility},
  year={2008},
  volume={20}
}
Abstract  The hallucinogenic plant Salvia divinorum has been used for medical treatments of gastrointestinal disorders. Here, we evaluated the effect of a standardized extract from the leaves of Salvia divinorum (SDE) and of its active ingredient salvinorin A on motility in vivo, both in physiological states and during croton oil‐induced intestinal inflammation. SDE (1–100 mg kg−1) significantly inhibited motility only in inflamed, but not in control, mice. In control mice, salvinorin A (0.01… 
Ultrapotent effects of salvinorin A, a hallucinogenic compound from Salvia divinorum, on LPS-stimulated murine macrophages and its anti-inflammatory action in vivo
TLDR
It is concluded that salvinorin A—via KORs and CB1 receptors—exerts ultrapotent actions on macrophages and also shows moderate antinflammatory effects in vivo.
Salvia divinorum: from recreational hallucinogenic use to analgesic and anti-inflammatory action
TLDR
The role of S. divinorum, SA and its analogues is explored, mainly on their analgesic and anti-inflammatory roles but also mention their psychoactive properties.
Salvia divinorum e seus efeitos biológicos: “A critical review on the toxicity of Salvia divinorum and its major constituent Salvinorin A”
TLDR
This review summarizes and updates the current knowledge about the biological properties of S. divinorum, highlighting the clinical, in vitro and in vivo findings, and intends to identify and to propose future directions for further research regarding the biological effects of this plant, particularly in CNS.
Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors*
TLDR
The results suggest that the drugs based on the structure of SA have the potential to become valuable antiinflammatory or analgesic therapeutics for the treatment of GI diseases.
Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis‐induced hypermotility: cross‐talk between κ‐opioid and cannabinoid CB1 receptors
TLDR
Because intestinal inflammation upregulates cannabinoid receptors and endogenous cannabinoids, the possible involvement of the endogenous cannabinoid system in salvinorin A‐induced delay in motility in the inflamed gut is investigated.
Anti-Inflammatory and Antihyperalgesic Activities of Ethanolic Extract and Fruticulin A from Salvia lachnostachys Leaves in Mice
The anti-inflammatory and analgesic effects of the ethanolic extract (SLEE) and fruticulin A from the leaves of Salvia lachnostachys were evaluated in mice, using experimental models of inflammation
The hallucinogenic diterpene salvinorin A inhibits leukotriene synthesis in experimental models of inflammation.
DARK Classics in Chemical Neuroscience: Salvinorin A.
TLDR
The chemistry behind and the taboo that encloses salvinorin A makes it one of the most exquisite naturally occurring drugs.
Pharmacokinetics and Pharmacodynamics of Salvinorin A and Salvia divinorum: Clinical and Forensic Aspects
TLDR
The aim of this work is to comprehensively review and discuss the toxicokinetics and toxicodynamics of S. divinorum and salvinorin A, highlighting their psychological, physiological, and toxic effects.
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