The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation‐induced hypermotility in mice
@article{Capasso2008TheHH, title={The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation‐induced hypermotility in mice}, author={Raffaele Capasso and Francesca Borrelli and Jordan K Zjawiony and Lukasz M. Kutrzeba and Gabriella Aviello and Giovanni Sarnelli and Francesco Capasso and Angelo A. Izzo}, journal={Neurogastroenterology \& Motility}, year={2008}, volume={20} }
Abstract The hallucinogenic plant Salvia divinorum has been used for medical treatments of gastrointestinal disorders. Here, we evaluated the effect of a standardized extract from the leaves of Salvia divinorum (SDE) and of its active ingredient salvinorin A on motility in vivo, both in physiological states and during croton oil‐induced intestinal inflammation. SDE (1–100 mg kg−1) significantly inhibited motility only in inflamed, but not in control, mice. In control mice, salvinorin A (0.01…
37 Citations
Antinociceptive effects of Salvia divinorum and bioactive salvinorins in experimental pain models in mice.
- Biology, MedicineJournal of ethnopharmacology
- 2019
Ultrapotent effects of salvinorin A, a hallucinogenic compound from Salvia divinorum, on LPS-stimulated murine macrophages and its anti-inflammatory action in vivo
- Biology, ChemistryJournal of Molecular Medicine
- 2011
It is concluded that salvinorin A—via KORs and CB1 receptors—exerts ultrapotent actions on macrophages and also shows moderate antinflammatory effects in vivo.
Salvia divinorum: from recreational hallucinogenic use to analgesic and anti-inflammatory action
- BiologyJournal of pain research
- 2019
The role of S. divinorum, SA and its analogues is explored, mainly on their analgesic and anti-inflammatory roles but also mention their psychoactive properties.
Salvia divinorum e seus efeitos biológicos: “A critical review on the toxicity of Salvia divinorum and its major constituent Salvinorin A”
- Biology
- 2015
This review summarizes and updates the current knowledge about the biological properties of S. divinorum, highlighting the clinical, in vitro and in vivo findings, and intends to identify and to propose future directions for further research regarding the biological effects of this plant, particularly in CNS.
Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors*
- Biology, MedicineInflammatory bowel diseases
- 2012
The results suggest that the drugs based on the structure of SA have the potential to become valuable antiinflammatory or analgesic therapeutics for the treatment of GI diseases.
Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis‐induced hypermotility: cross‐talk between κ‐opioid and cannabinoid CB1 receptors
- Medicine, BiologyBritish journal of pharmacology
- 2008
Because intestinal inflammation upregulates cannabinoid receptors and endogenous cannabinoids, the possible involvement of the endogenous cannabinoid system in salvinorin A‐induced delay in motility in the inflamed gut is investigated.
Anti-Inflammatory and Antihyperalgesic Activities of Ethanolic Extract and Fruticulin A from Salvia lachnostachys Leaves in Mice
- Medicine, BiologyEvidence-based complementary and alternative medicine : eCAM
- 2014
The anti-inflammatory and analgesic effects of the ethanolic extract (SLEE) and fruticulin A from the leaves of Salvia lachnostachys were evaluated in mice, using experimental models of inflammation…
The hallucinogenic diterpene salvinorin A inhibits leukotriene synthesis in experimental models of inflammation.
- Biology, MedicinePharmacological research
- 2016
DARK Classics in Chemical Neuroscience: Salvinorin A.
- ChemistryACS chemical neuroscience
- 2020
The chemistry behind and the taboo that encloses salvinorin A makes it one of the most exquisite naturally occurring drugs.
Pharmacokinetics and Pharmacodynamics of Salvinorin A and Salvia divinorum: Clinical and Forensic Aspects
- Biology, MedicinePharmaceuticals
- 2021
The aim of this work is to comprehensively review and discuss the toxicokinetics and toxicodynamics of S. divinorum and salvinorin A, highlighting their psychological, physiological, and toxic effects.
References
SHOWING 1-10 OF 31 REFERENCES
The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A inhibit enteric cholinergic transmission in the guinea‐pig ileum
- Biology, MedicineNeurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
- 2006
It is concluded that SDE depressed enteric cholinergic transmission likely through activation of κ‐opioid receptors and this may provide the pharmacological basis underlying its traditional antidiarrhoeal use.
Salvinorin A, an Active Component of the Hallucinogenic Sage Salvia divinorum Is a Highly Efficacious κ-Opioid Receptor Agonist: Structural and Functional Considerations
- Biology, ChemistryJournal of Pharmacology and Experimental Therapeutics
- 2004
Salvinorin A was found to be a full agonist, being significantly more efficacious than (trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl] benzeneacetamide methane-sulfonate hydrate (U69593) and similar in efficacy to dynorphin A (the naturally occurring peptide ligand for κ-opioid receptors).
Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 2002
Salvinorin A is the first naturally occurring nonnitrogenous opioid-receptor subtype-selective agonist for κ opioid receptors and may represent novel psychotherapeutic compounds for diseases manifested by perceptual distortions (e.g., schizophrenia, dementia, and bipolar disorders).
Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.
- Biology, PsychologyProceedings of the National Academy of Sciences of the United States of America
- 2002
Salvinorin A is the first naturally occurring nonnitrogenous opioid-receptor subtype-selective agonist for kappa opioid receptors, and may represent novel psychotherapeutic compounds for diseases manifested by perceptual distortions (e.g., schizophrenia, dementia, and bipolar disorders).
Salvinorin A: from natural product to human therapeutics.
- BiologyMolecular interventions
- 2006
The hallucinogenic plant Salvia divinorum (i.e., "magic mint") is a member of the Sage family that has been used for divination and shamanism by the Mazatecs. Over the past decade or so, S. divinorum…
Salvia divinorum and salvinorin A: new pharmacologic findings.
- MedicineJournal of ethnopharmacology
- 1994
Ethnopharmacology of ska María Pastora (Salvia divinorum, Epling and Játiva-M.).
- LinguisticsJournal of ethnopharmacology
- 1983
Inhibitory effect of palmitoylethanolamide on gastrointestinal motility in mice
- Biology, MedicineBritish journal of pharmacology
- 2001
It is concluded that PEA inhibits intestinal motility with a peripheral mechanism independent from cannabinoid receptor activation and might contribute, at least in part, to the exaggerated transit observed during chronic intestinal inflammation.
Salvinorin A: the "magic mint" hallucinogen finds a molecular target in the kappa opioid receptor.
- Chemistry, BiologyTrends in pharmacological sciences
- 2003
Peripheral effects of opioids in a model of chronic intestinal inflammation in mice.
- Biology, MedicineThe Journal of pharmacology and experimental therapeutics
- 1998
The results suggest an increase in the active concentration of mu-opioid receptors during chronic inflammation, which could be related to weight loss and GI transit in mice induced by chronic CO.