The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation‐induced hypermotility in mice

@article{Capasso2008TheHH,
  title={The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation‐induced hypermotility in mice},
  author={R. Capasso and F. Borrelli and J. Zjawiony and L. Kutrzeba and G. Aviello and G. Sarnelli and F. Capasso and A. Izzo},
  journal={Neurogastroenterology & Motility},
  year={2008},
  volume={20}
}
Abstract  The hallucinogenic plant Salvia divinorum has been used for medical treatments of gastrointestinal disorders. Here, we evaluated the effect of a standardized extract from the leaves of Salvia divinorum (SDE) and of its active ingredient salvinorin A on motility in vivo, both in physiological states and during croton oil‐induced intestinal inflammation. SDE (1–100 mg kg−1) significantly inhibited motility only in inflamed, but not in control, mice. In control mice, salvinorin A (0.01… Expand
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References

SHOWING 1-10 OF 31 REFERENCES
The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A inhibit enteric cholinergic transmission in the guinea‐pig ileum
  • R. Capasso, F. Borrelli, +4 authors A. Izzo
  • Chemistry, Medicine
  • Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2006
Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist
  • B. Roth, K. Baner, +5 authors R. Rothman
  • Chemistry
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2002
Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.
  • B. Roth, K. Baner, +5 authors R. Rothman
  • Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2002
Salvinorin A: from natural product to human therapeutics.
Salvia divinorum and salvinorin A: new pharmacologic findings.
  • D. Siebert
  • Biology, Medicine
  • Journal of ethnopharmacology
  • 1994
Inhibitory effect of palmitoylethanolamide on gastrointestinal motility in mice
Peripheral effects of opioids in a model of chronic intestinal inflammation in mice.
  • M. Puig, O. Pol
  • Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1998
...
1
2
3
4
...