The hairpin stack fold, a novel protein architecture for a new family of protein growth factors

@article{Hrabal1996TheHS,
  title={The hairpin stack fold, a novel protein architecture for a new family of protein growth factors},
  author={Richard Hrabal and Zhigang Chen and Susan James and Hugh P.J. Bennett and Feng Ni},
  journal={Nature Structural Biology},
  year={1996},
  volume={3},
  pages={747-752}
}
The granulin/epithelin protein motif has an unusual structure consisting of a parallel stack of beta-hairpins stapled together by six disulphide bonds. The new structure also contains a folding subdomain shared by small toxins, protease inhibitors as well as the EGF-like protein modules.