The hairpin conformation of the amyloid β peptide is an important structural motif along the aggregation pathway

@article{Abelein2014TheHC,
  title={The hairpin conformation of the amyloid β peptide is an important structural motif along the aggregation pathway},
  author={Axel Abelein and Jan Pieter Abrahams and Jens Danielsson and Astrid Gr{\"a}slund and J{\"u}ri Jarvet and Jinghui Luo and Ann Tiiman and Sebastian K T S W{\"a}rml{\"a}nder},
  journal={JBIC Journal of Biological Inorganic Chemistry},
  year={2014},
  volume={19},
  pages={623-634}
}
The amyloid β (Aβ) peptides are 39–42 residue-long peptides found in the senile plaques in the brains of Alzheimer’s disease (AD) patients. These peptides self-aggregate in aqueous solution, going from soluble and mainly unstructured monomers to insoluble ordered fibrils. The aggregation process(es) are strongly influenced by environmental conditions… CONTINUE READING