The hair cell acetylcholine receptors: a synthesis.


In this article the evidence concerning the nature of the acetylcholine (ACh) receptors on hair cells is reviewed. A schematic organization of these receptors is offered, based on the evidence as follows. (1) There are two kinds of ACh receptors on hair cells: muscarinic-like and nicotinic-like. (2) The nicotinic-like receptor mediates a hyperpolarizing response to ACh and a consequent reduction in afferent firing. (3) The muscarinic-like receptors mediate both a depolarization and a hyperpolarization of hair cells. (4) The hyperpolarization results in a reduction in afferent firing and (5) the depolarization results in an increase in afferent firing.

Cite this paper

@article{Guth1996TheHC, title={The hair cell acetylcholine receptors: a synthesis.}, author={Paul S. Guth and Carolyn Norris}, journal={Hearing research}, year={1996}, volume={98 1-2}, pages={1-8} }