The haemopoietic growth factor, Flt3L, alters the immune response induced by transcutaneous immunization.

@article{BacaEstrada2002TheHG,
  title={The haemopoietic growth factor, Flt3L, alters the immune response induced by transcutaneous immunization.},
  author={Maria E. Baca-Estrada and Catherine Ewen and Donna Mahony and Lorne A. Babiuk and Darryl Wilkie and Marianna Foldvari},
  journal={Immunology},
  year={2002},
  volume={107 1},
  pages={69-76}
}
Topical application of antigen induces antigen-specific humoral and cellular immune responses. In this study we examined whether expansion of dendritic cells (DC) by Flt3 ligand (Flt3L) treatment influences the induction of immune responses following transcutaneous immunization. Mice were treated intraperitoneally with Flt3L or phosphate-buffered saline (PBS) and immunized transcutaneously with hen egg lysozyme (HEL). Flt3L-treated mice developed lower HEL-specific cellular and humoral immune… CONTINUE READING
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