The ha72 core gene of baculovirus is essential for budded virus production and occlusion-derived virus embedding, and amino acid K22 plays an important role in its function.

@article{Huang2014TheHC,
  title={The ha72 core gene of baculovirus is essential for budded virus production and occlusion-derived virus embedding, and amino acid K22 plays an important role in its function.},
  author={Huachao Huang and Manli Wang and Fei Deng and Dianhai Hou and Basil M. Arif and Hualin Wang and Zhihong Hu},
  journal={Journal of virology},
  year={2014},
  volume={88 1},
  pages={705-9}
}
ha72 of Helicoverpa armigera nucleopolyhedrovirus (a homologue of ac78) was identified as a conserved late baculovirus gene and characterized. HA72 localizes in the intranuclear ring zone. By generating mutants, we showed that HA72 is essential for budded virus (BD) production and occlusion-derived virus (ODV) embedding. HA72 also interacted with P33, a baculoviral sulfhydryl oxidase. A point mutation of amino acid 22 from lysine to glutamic acid curtailed BV production and precluded ODV… CONTINUE READING