The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

@article{Carney1998TheHP,
  title={The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response},
  author={James P. Carney and Richard S. Maser and Heidi A. Olivares and Elizabeth M. Davis and Michelle M. Le Beau and John R. Yates and Lara G Hays and William F. Morgan and John H.J Petrini},
  journal={Cell},
  year={1998},
  volume={93},
  pages={477-486}
}
Nijmegen breakage syndrome (NBS) is an autosomal recessive disorder characterized by increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity. We have isolated the gene encoding p95, a member of the hMre11/hRad50 double-strand break repair complex. The p95 gene mapped to 8q21.3, the region that contains the NBS locus… CONTINUE READING