The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

@inproceedings{Kimura2013TheGM,
  title={The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43},
  author={Ikuo Kimura and Kentaro Ozawa and D Inoue and Takeshi Imamura and Kumi Kimura and Takeshi Maeda and Kazuya Terasawa and Daiji Kashihara and Kanako Hirano and Taeko Tani and Tomoyuki Takahashi and Satoshi Miyauchi and Go Shioi and Hiroshi Inoue and Gozoh Tsujimoto},
  booktitle={Nature communications},
  year={2013}
}
The gut microbiota affects nutrient acquisition and energy regulation of the host, and can influence the development of obesity, insulin resistance, and diabetes. During feeding, gut microbes produce short-chain fatty acids, which are important energy sources for the host. Here we show that the short-chain fatty acid receptor GPR43 links the metabolic activity of the gut microbiota with host body energy homoeostasis. We demonstrate that GPR43-deficient mice are obese on a normal diet, whereas… CONTINUE READING
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