The gut microbiota shapes intestinal immune responses during health and disease

@article{Round2009TheGM,
  title={The gut microbiota shapes intestinal immune responses during health and disease},
  author={June L Round and S K Mazmanian},
  journal={Nature Reviews Immunology},
  year={2009},
  volume={9},
  pages={313-323}
}
Immunological dysregulation is the cause of many non-infectious human diseases such as autoimmunity, allergy and cancer. The gastrointestinal tract is the primary site of interaction between the host immune system and microorganisms, both symbiotic and pathogenic. In this Review we discuss findings indicating that developmental aspects of the adaptive immune system are influenced by bacterial colonization of the gut. We also highlight the molecular pathways that mediate host–symbiont… CONTINUE READING
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Effect of intestinal microbiota on the induction of regulatory CD 25 + CD 4 + T cells

  • H. Ishikawa
  • Clin . Exp . Immunol .
  • 2008

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