The gut microbiota shapes intestinal immune responses during health and disease

  title={The gut microbiota shapes intestinal immune responses during health and disease},
  author={June L Round and S K Mazmanian},
  journal={Nature Reviews Immunology},
Immunological dysregulation is the cause of many non-infectious human diseases such as autoimmunity, allergy and cancer. The gastrointestinal tract is the primary site of interaction between the host immune system and microorganisms, both symbiotic and pathogenic. In this Review we discuss findings indicating that developmental aspects of the adaptive immune system are influenced by bacterial colonization of the gut. We also highlight the molecular pathways that mediate host–symbiont… CONTINUE READING
Highly Influential
This paper has highly influenced 32 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 22 times over the past 90 days. VIEW TWEETS
1,160 Citations
93 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 1,160 extracted citations


Publications referenced by this paper.
Showing 1-10 of 93 references

Effect of intestinal microbiota on the induction of regulatory CD 25 + CD 4 + T cells

  • H. Ishikawa
  • Clin . Exp . Immunol .
  • 2008

Similar Papers

Loading similar papers…