The gut microbiota, bacterial metabolites and colorectal cancer

  title={The gut microbiota, bacterial metabolites and colorectal cancer},
  author={Petra Louis and Georgina L. Hold and Harry James Flint},
  journal={Nature Reviews Microbiology},
Accumulating evidence suggests that the human intestinal microbiota contributes to the aetiology of colorectal cancer (CRC), not only via the pro-carcinogenic activities of specific pathogens but also via the influence of the wider microbial community, particularly its metabolome. Recent data have shown that the short-chain fatty acids acetate, propionate and butyrate function in the suppression of inflammation and cancer, whereas other microbial metabolites, such as secondary bile acids… 

Figures from this paper

Intestinal microbiota, chronic inflammation, and colorectal cancer
The bacterial taxa associated with CRC are described, including Fusobacterium nucleatum, enterotoxigenic Bacteroides fragilis, Escherichia coli, and butyrate-producing bacteria, and the host-diet interaction in colorectal carcinogenesis is discussed.
Microbial Metabolites in Colorectal Cancer: Basic and Clinical Implications
The present metabolomics techniques in microbial metabolites researches and the mechanisms of microbial metabolites in CRC pathogenesis are summarized and the potential clinical applications of microbial metabolites in cancer diagnosis and treatment are discussed.
The inhibitory effect of gut microbiota and its metabolites on colorectal cancer.
The aim of this review is to develop a possible therapeutic method, which use the products of gut microbiota metabolism or gut microbiota constituents to help treat or prevent colorectal cancer.
Microbial Interactions and Interventions in Colorectal Cancer.
The potential for gut microbial modulation therapies, for example, probiotics, antibiotics, and others, to target and improve gut microbial dysbiosis as a strategy for the prevention or treatment of CRC is discussed.
The Role of the Gut Microbiome in Colorectal Cancer.
  • Grace Y Chen
  • Biology, Medicine
    Clinics in colon and rectal surgery
  • 2018
Studies in mice strongly suggest that the gut microbiota can modulate susceptibility to CRC, and therefore may serve as both biomarkers and therapeutic targets.
The gastrointestinal microbiota and colorectal cancer.
An overview on the role of commensal gut microbiota in the development of human CRC is provided and its association with diet and inflammation is explored.
Gut Bacteria and their Metabolites: Which One Is the Defendant for Colorectal Cancer?
Most of the studies on the modifications of gut bacteria detected in stool and tissue samples of CRC cases are reviewed, including the importance of metabolites derived from gut bacteria, their relationship with the microbiota, and epigenetic modifications have been evaluated.
Role of Gut Microbiota in the Development and Treatment of Colorectal Cancer
This review seeks to outline the relationship between gut microbiota and the development of CRC as well as the potential mechanisms of microbiota involved in treatment of CRC so as to provide some references for research on the development, prevention, and treatment of this disease.
The role of microbiota in the development of colorectal cancer
By gaining a deeper understanding of the intestinal microbiota, it is hoped that the goal of treating colorectal cancer using current microbiota technologies, such as fecal microbiological transplantation, will be achieved.
The Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response
A personalized modulation of the pattern of gut microbiome by diet may be a promising approach to prevent the development and progression of CRC and to improve the efficacy of antitumoral therapy.


Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans.
The hypothesis that colon cancer risk is influenced by the balance between microbial production of health-promoting metabolites such as butyrate and potentially carcinogenic metabolitessuch as secondary bile acids is supported.
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis
This study determined that short-chain fatty acids, gut microbiota–derived bacterial fermentation products, regulate the size and function of the colonic Treg pool and protect against colitis in a Ffar2-dependent manner in mice, revealing that a class of abundant microbial metabolites underlies adaptive immune microbiota coadaptation and promotes colonic homeostasis and health.
Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota
High-throughput sequencing revealed that inflammation modifies gut microbial composition in colitis-susceptible interleukin-10–deficient (Il10−/−) mice, suggesting that in mice, colitis can promote tumorigenesis by altering microbial composition and inducing the expansion of microorganisms with genotoxic capabilities.
The role of the gut microbiota in nutrition and health
The complex interplay between the gut microbiota, diet and health is considered and better definition of those dominant commensal bacteria, community profiles and system characteristics that produce stable gut communities beneficial to health is important.
Relevance of protein fermentation to gut health.
It is generally accepted that carbohydrate fermentation results in beneficial effects for the host because of the generation of short chain fatty acids, whereas protein fermentation is considered
Metabolic Activities of the Gut Microflora in Relation to Cancer
The interrelationships between diet, gut microflora metabolism and effects on the host are complicated however they may be important in the understanding of epidemiological associations between exogenous factors and colorectal cancer risk.