The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system.

@article{Nakahara2004TheGP,
  title={The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system.},
  author={Keiko Nakahara and Reiko Hanada and Noboru Murakami and Hitoshi Teranishi and Hideko Ohgusu and Nobuhiro Fukushima and Maiko Moriyama and Takanori Ida and Kenji Kangawa and Masayasu Kojima},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={318 1},
  pages={156-61}
}
Immunohistochemical analysis revealed the presence of a gut-brain peptide, neuromedin U (NMU), in the suprachiasmatic nucleus (SCN), which is the site of the master circadian oscillator. The expression of NMU mRNA exhibited a circadian rhythm, with the peak expression in the SCN occurring at CT4-8h. The two NMU-binding receptors (NMU-R1 and NMU-R2) were… CONTINUE READING