The gut as communicator between environment and host: immunological consequences.

@article{Brandtzaeg2011TheGA,
  title={The gut as communicator between environment and host: immunological consequences.},
  author={P E R Brandtzaeg},
  journal={European journal of pharmacology},
  year={2011},
  volume={668 Suppl 1},
  pages={S16-32}
}
During human evolution, the mucosal immune system developed two anti-inflammatory mechanisms: immune exclusion by secretory antibodies (SIgA and SIgM) to control epithelial colonization of microorganisms and inhibit penetration of harmful substances; and immunosuppression to counteract local and peripheral hypersensitivity against innocuous antigens such as food proteins. The latter function is referred to as oral tolerance when induced via the gut. Similar mechanisms also control immunity to… CONTINUE READING