The guinea-pig is not a rodent

@article{DErchia1996TheGI,
  title={The guinea-pig is not a rodent},
  author={Anna Maria D’Erchia and Carmela Gissi and Graziano Pesole and Cecilia Saccone and {\'U}lfur {\'A}rnason},
  journal={Nature},
  year={1996},
  volume={381},
  pages={597-600}
}
IN 1991 Graur et al. raised the question of whether the guinea-pig, Cavia porcellus, is a rodent1. They suggested that the guinea-pig and myomorph rodents diverged before the separation between myomorph rodents and a lineage leading to primates and artiodactyls. Several findings have since been reported, both for and against this phylogeny, thereby highlighting the issue of the validity of molecular analysis in mammalian phylogeny. Here we present findings based on the sequence of the complete… Expand
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TLDR
The phylogenetic analyses of amino-acid sequence data imply that the guinea-pig diverged before the separation of the primates and the artiodactyls from the myomorph rodents (rats and mice), which would represent an early divergence in eutherian radiation. Expand
Phylogenetic place of guinea pigs: no support of the rodent-polyphyly hypothesis from maximum-likelihood analyses of multiple protein sequences.
TLDR
The overall evidence does not support Graur et al.'s hypothesis, which radically contradicts the traditional view of rodent monophyly, and demonstrates that one must be careful in choosing a proper method for phylogenetic inference and that an argument based on a small data set (with respect to the length of the sequence and especially the number of species) may be unstable. Expand
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The phylogenetic relationships among the major clades of eutherian mammals, Primates, Cetacea, Artiodactyla, Carnivora, Lagomorpha, Myom orpha, and Caviomorbpha, were analyzed by the maximum likelihood (ML) method, which favors the closer affinity of LagomOrpha to Primates than to Rodentia. Expand
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It is shown that Lagomorpha is significantly more closely related to Primates and Scandentia (tree shrews) than it is to rodents, which raises the possibility that the ancestral eutherian morphotype may have possessed many rodent-like morphological characters. Expand
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The degree of similarity of the sequences suggests that the mammalian clade diverged into rodents, primates, lagomorphs and caviomorphs at about the same time. Expand
Monophyly of the order Rodentia inferred from mitochondrial DNA sequences of the genes for 12S rRNA, 16S rRNA, and tRNA-valine.
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Analysis of the mitochondrial genome of the guinea pig and neighbor-joining analyses of all available sequence data confirm that some individual genes support rodent polyphyly but that tandem analysis of all data does not, and propose that the conflicting results are due to several compounding factors. Expand
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It is estimated that all but 109 of the 1019 possible phylogenetic trees have been ruled out by molecular analysis, and that DNA and protein sequences with their potential to supply millions of phylogenetically useful characters will resolve the phylogeny of the orders of mammals into a consistently bifurcating tree in the not‐so‐distant future. Expand
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It is estimated that the whale lineage has branched off a protoruminant lineage < 50 Mya, and the cetacean transition to aquatic life is inferred to be a relatively recent evolutionary event. Expand
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TLDR
Comparison among the peptide-coding genes of the horse and eight other mammals suggests that the boundaries of some mt genes should be redefined. Expand
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