The guanylyl cyclase activator YC-1 directly inhibits the voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells.

@article{Park2010TheGC,
  title={The guanylyl cyclase activator YC-1 directly inhibits the voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells.},
  author={Won Sun Park and Jae-Hong Ko and Eun Ah Ko and Youn Kyoung Son and Da Hye Hong and In Duk Jung and Yeong-min Park and Tae-hoon Choi and Nari Kim and Jin Han},
  journal={Journal of pharmacological sciences},
  year={2010},
  volume={112 1},
  pages={
          64-72
        }
}
We investigated the effects of YC-1, an activator of soluble guanylyl cyclase (sGC), on voltage-dependent K+ (Kv) channels in smooth muscle cells from freshly isolated rabbit coronary arteries by using the whole-cell patch clamp technique. YC-1 inhibited the Kv current in a dose-dependent fashion with an apparent K(d) of 9.67 microM. It accelerated the decay rate of Kv channel inactivation without altering the kinetics of current activation. The rate constants of association and dissociation… CONTINUE READING

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