The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression.

@article{Guenzi2003TheGB,
  title={The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression.},
  author={Eric Guenzi and Kristin T{\"o}polt and Clara Lubeseder-Martellato and Anita J{\"o}rg and Elisabeth Naschberger and Roberto Benelli and Adriana Albini and Michael St{\"u}rzl},
  journal={The EMBO journal},
  year={2003},
  volume={22 15},
  pages={3772-82}
}
Expression of the large GTPase guanylate binding protein-1 (GBP-1) is induced by inflammatory cytokines (ICs) in endothelial cells (ECs), and the helical domain of the molecule mediates the repression of EC proliferation by ICs. Here we show that the expression of GBP-1 and of the matrix metalloproteinase-1 (MMP-1) are inversely related in vitro and in vivo, and that GBP-1 selectively inhibits the expression of MMP-1 in ECs, but not the expression of other proteases. The GTPase activity of GBP… CONTINUE READING

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