The growth threshold conjecture: a theoretical framework for understanding T-cell tolerance

@inproceedings{Arias2015TheGT,
  title={The growth threshold conjecture: a theoretical framework for understanding T-cell tolerance},
  author={Clemente Fernandez Arias and Miguel A. Herrero and Jos{\'e} A Cuesta and Francisco Javier Acosta and Cristina Fern{\'a}ndez-Arias},
  booktitle={Royal Society open science},
  year={2015}
}
Adaptive immune responses depend on the capacity of T cells to target specific antigens. As similar antigens can be expressed by pathogens and host cells, the question naturally arises of how can T cells discriminate friends from foes. In this work, we suggest that T cells tolerate cells whose proliferation rates remain below a permitted threshold. Our proposal relies on well-established facts about T-cell dynamics during acute infections: T-cell populations are elastic (they expand and… CONTINUE READING
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