The growth promoting and antisulfonamide activity of pteroylglutamic acid and related compounds for Escherichia coli and Aerobacter aerogenes.


A basis for understanding the mode of action of sulfonamide drugs in terms of the WoodsFildes theory of antagonism (Woods, 1940; Fildes, 1940) was provided by the elucidation of the structure of folic acid (Stokstad et al., 1946; Angier et al., 1946; Mowat et al., 1948). Since folic acid contains a p-aminobenzoic acid moiety, it was postulated that the… (More)


5 Figures and Tables