The growth promoting and antisulfonamide activity of pteroylglutamic acid and related compounds for Escherichia coli and Aerobacter aerogenes.

@article{Havas1953TheGP,
  title={The growth promoting and antisulfonamide activity of pteroylglutamic acid and related compounds for Escherichia coli and Aerobacter aerogenes.},
  author={H. Francis Havas and A P McGEADY},
  journal={Journal of bacteriology},
  year={1953},
  volume={66 5},
  pages={
          531-7
        }
}
A basis for understanding the mode of action of sulfonamide drugs in terms of the WoodsFildes theory of antagonism (Woods, 1940; Fildes, 1940) was provided by the elucidation of the structure of folic acid (Stokstad et al., 1946; Angier et al., 1946; Mowat et al., 1948). Since folic acid contains a p-aminobenzoic acid moiety, it was postulated that the structurally similar sulfonamides compete with p-aminobenzoic acid for a site in the folic acid synthesizing system (Jukes and Stokstad, 1948… CONTINUE READING

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