The growth of brain tumors can be suppressed by multiple transplantation of mesenchymal stem cells expressing cytosine deaminase.

@article{Chang2010TheGO,
  title={The growth of brain tumors can be suppressed by multiple transplantation of mesenchymal stem cells expressing cytosine deaminase.},
  author={D Chang and Seung-Wan Yoo and Youngtae Hong and Sunyoung Kim and Se Joong Kim and Sung-Hwa Yoon and K Cho and Sun Ha Paek and Young-don Lee and Sung-Soo Kim and Haeyoung Suh-Kim},
  journal={International journal of cancer},
  year={2010},
  volume={127 8},
  pages={1975-83}
}
Suicide genes have recently emerged as an attractive alternative therapy for the treatment of various types of intractable cancers. The efficacy of suicide gene therapy relies on efficient gene delivery to target tissues and the localized concentration of final gene products. Here, we showed a potential ex vivo therapy that used mesenchymal stem cells (MSCs) as cellular vehicles to deliver a bacterial suicide gene, cytosine deaminase (CD) to brain tumors. MSCs were engineered to produce CD… CONTINUE READING

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