The growth hormone receptor: mechanism of activation and clinical implications

@article{Brooks2010TheGH,
  title={The growth hormone receptor: mechanism of activation and clinical implications},
  author={A. Brooks and M. Waters},
  journal={Nature Reviews Endocrinology},
  year={2010},
  volume={6},
  pages={515-525}
}
Growth hormone is widely used clinically to promote growth and anabolism and for other purposes. Its actions are mediated via the growth hormone receptor, both directly by tyrosine kinase activation and indirectly by induction of insulin-like growth factor 1 (IGF-1). Insensitivity to growth hormone (Laron syndrome) can result from mutations in the growth hormone receptor and can be treated with IGF-1. This treatment is, however, not fully effective owing to the loss of the direct actions of… Expand
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