The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.

@article{Tang2011TheGF,
  title={The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.},
  author={Wei Tang and Yi Lu and Qing-yun Tian and Yan Zhang and Feng-Jin Guo and Guang-yi Liu and Nabeel Muzaffar Syed and Yongjie Lai and Edward Alan Lin and Li Yin Kong and Jeffrey Y Su and Fangfang Yin and Ai-Hao Ding and Alexandra Zanin-Zhorov and Michael L. Dustin and Jian L Tao and Joseph F Craft and Zhinan Yin and Jian Feng and Steven B. Abramson and Xiu-ping Yu and Chuan-Ju Liu},
  journal={Science},
  year={2011},
  volume={332 6028},
  pages={478-84}
}
The growth factor progranulin (PGRN) has been implicated in embryonic development, tissue repair, tumorigenesis, and inflammation, but its receptors remain unidentified. We report that PGRN bound directly to tumor necrosis factor receptors (TNFRs) and disturbed the TNFα-TNFR interaction. PGRN-deficient mice were susceptible to collagen-induced arthritis, and administration of PGRN reversed inflammatory arthritis. Atsttrin, an engineered protein composed of three PGRN fragments, exhibited… CONTINUE READING
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