The growth cone cytoskeleton. Glycoprotein association, calmodulin binding, and tyrosine/serine phosphorylation of tubulin.


Cytoskeletons were prepared from the growth cones of neonatal rat forebrains and were utilized to explore several aspects of growth cone function. The cytoskeletal fraction retained about 50% of total growth cone protein, was highly enriched in tubulin, and constituted an interconnected lattice of 10-25 nm homogeneous particles. The cytoskeleton appeared to… (More)


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