The growing importance of PON1 in cardiovascular health: a review.

@article{Macharia2012TheGI,
  title={The growing importance of PON1 in cardiovascular health: a review.},
  author={Muiruri Macharia and Mogamat Shafick Hassan and Diane M Blackhurst and Rajiv Timothy Erasmus and Tandi E Matsha},
  journal={Journal of cardiovascular medicine},
  year={2012},
  volume={13 7},
  pages={443-53}
}
The wide acceptance of the oxidation theory of atherogenesis has prompted attention to antioxidant mechanisms, particularly the prevention of lipid oxidation by high-density lipoprotein-associated proteins like paraoxonase 1 (PON1) enzyme. PON1 is a calcium-dependent enzyme that has interested toxicologists since its discovery as an organophosphate hydrolase. There is a growing interest in the enzyme's importance in cardiovascular health prompted by evidence that it may have a role in lipid… CONTINUE READING