The growing impact of click chemistry on drug discovery.

@article{Kolb2003TheGI,
  title={The growing impact of click chemistry on drug discovery.},
  author={Hartmuth C. Kolb and K. Barry Sharpless},
  journal={Drug discovery today},
  year={2003},
  volume={8 24},
  pages={1128-37}
}
Click chemistry is a modular approach that uses only the most practical and reliable chemical transformations. Its applications are increasingly found in all aspects of drug discovery, ranging from lead finding through combinatorial chemistry and target-templated in situ chemistry, to proteomics and DNA research, using bioconjugation reactions. The copper-(I)-catalyzed 1,2,3-triazole formation from azides and terminal acetylenes is a particularly powerful linking reaction, due to its high… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
Blog posts, news articles and tweet counts and IDs sourced by
Altmetric.com