The group at C2 of N-ethylnicotinamide determines the vasodilator potencies and mechanisms of action of nicorandil and its congeners in canine coronary arteries

@article{Satoh2004TheGA,
  title={The group at C2 of N-ethylnicotinamide determines the vasodilator potencies and mechanisms of action of nicorandil and its congeners in canine coronary arteries},
  author={K. Satoh and H. Yamada and F. Yoneyama and N. Taira},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={344},
  pages={589-595}
}
SummaryThe relaxant mechanisms of action of nicorandil and its congeners (SG-86, SG-103, SG-209 and SG-212) on large coronary arteries were investigated in isolated canine circumflex arteries contracted with 25 mmol/l KCl or 10−7 mol/l U46619, a thromboxane A2 analogue. SG-212, SG-86, SG-209 and SG-103 were obtained by replacement of the nitroxy group of nicorandil by bromine, the hydroxy, acetoxy and nicotinoyloxy groups, respectively.Nicorandil (10−6–10−3 mol/l), SG-212 (3 × 10−4 –10−2 mol/l… Expand

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