The group A streptococcal virR49 gene controls expression of four structural vir regulon genes.

@article{Podbielski1995TheGA,
  title={The group A streptococcal virR49 gene controls expression of four structural vir regulon genes.},
  author={Andreas Podbielski and A Flosdorff and Josefine Weber-Heynemann},
  journal={Infection and immunity},
  year={1995},
  volume={63 1},
  pages={9-20}
}
Within a genomic locus termed the vir regulon, virR genes of opacity factor-nonproducing (OF-) group A streptococci (GAS) are known to control the expression of the genes encoding M protein (emm) and C5a peptidase (scpA) and of virR itself. Within the corresponding genomic locus, opacity factor-producing (OF+) GAS harbor additional emm-related genes encoding immunoglobulin G- and immunoglobulin A-binding proteins (fcrA and enn, respectively). The virR gene region of the OF+ GAS M-type 49 strain… CONTINUE READING

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