The great escape: structure and function of the autotransporter proteins.

  title={The great escape: structure and function of the autotransporter proteins.},
  author={Ian R. Henderson and Fernando Navarro-Garc{\'i}a and James P Nataro},
  journal={Trends in microbiology},
  volume={6 9},
The autotransporters, a family of secreted proteins from Gram-negative bacteria, possess an overall unifying structure comprising three functional domains: the amino-terminal leader sequence, the secreted mature protein (passenger domain) and a carboxy-terminal (beta-) domain that forms a beta-barrel pore to allow secretion of the passenger protein. Members of this family have been implicated as important or putative virulence factors in many Gram-negative pathogens. 
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