The gray platelet syndrome: clinical spectrum of the disease.

@article{Nurden2007TheGP,
  title={The gray platelet syndrome: clinical spectrum of the disease.},
  author={Paquita Nurden},
  journal={Blood reviews},
  year={2007},
  volume={21 1},
  pages={21-36}
}
The gray platelet syndrome (GPS) is a rare inherited disorder of the megakaryocyte (MK) lineage. Thrombocytopenia and enlarged platelets are associated with a specific absence of alpha-granules and their contents. GPS patients exhibit much heterogeneity both in bleeding severity and in their response to platelet function testing. A unique feature is that proteins endogenously synthesised by megakaryocytes (MK) or endocytosed by MK or platelets fail to enter into the secretable storage pools… CONTINUE READING
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