The granzyme B-serglycin complex from cytotoxic granules requires dynamin for endocytosis.

@article{Veugelers2004TheGB,
  title={The granzyme B-serglycin complex from cytotoxic granules requires dynamin for endocytosis.},
  author={Kirstin Veugelers and Bruce Motyka and Christine Frantz and Irene Shostak and Tracy Sawchuk and Robert Chris Bleackley},
  journal={Blood},
  year={2004},
  volume={103 10},
  pages={3845-53}
}
Cytotoxic T lymphocytes and natural killer cells destroy target cells via the directed exocytosis of lytic effector molecules such as perforin and granzymes. The mechanism by which these proteins enter targets is uncertain. There is ongoing debate over whether the most important endocytic mechanism is nonspecific or is dependent on the cation-independent… CONTINUE READING