The granular chloride channel ClC-3 is permissive for insulin secretion.


Insulin secretion from pancreatic beta cells is dependent on maturation and acidification of the secretory granule, processes necessary for prohormone convertase cleavage of proinsulin. Previous studies in isolated beta cells revealed that acidification may be dependent on the granule membrane chloride channel ClC-3, in a step permissive for a regulated… (More)
DOI: 10.1016/j.cmet.2009.08.012


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