The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure.

@article{Fargali2014TheGV,
  title={The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure.},
  author={Samira Fargali and Angelo L. Garcia and Masato Sadahiro and Cheng Jiang and William G. M. Janssen and W Lin and Valeria Cogliani and Alice M Elste and Steven Mortillo and Cheryl Cero and Britta J Veitenheimer and Gallia Graiani and Giulio Maria Pasinetti and Sushil K Mahata and John W. Osborn and George W Huntley and Greg R Phillips and Deanna L. Benson and Alessandro Bartolomucci and Stephen R J Salton},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2014},
  volume={28 5},
  pages={2120-33}
}
Secretion of proteins and neurotransmitters from large dense core vesicles (LDCVs) is a highly regulated process. Adrenal LDCV formation involves the granin proteins chromogranin A (CgA) and chromogranin B (CgB); CgA- and CgB-derived peptides regulate catecholamine levels and blood pressure. We investigated function of the granin VGF (nonacronymic) in LDCV formation and the regulation of catecholamine levels and blood pressure. Expression of exogenous VGF in nonendocrine NIH 3T3 fibroblasts… CONTINUE READING