The gramicidin a channel as a 2-site pore: Evaluation of the kinetic parameters from measurements of the flux-ratio exponent

As has been shown by Hladky et al. for different cation species, conductance measurements of the gramicidin A channel in lipid bilayers can be interpreted in terms of a 2-site single-file pore model (I). Measurements of the flux-ratio exponent n (2,3) give additional support to this conclusion. Near chemical equilibrium, the permeation of a single cation… CONTINUE READING