The gramicidin a channel: A review of its permeability characteristics with special reference to the single-file aspect of transport

@article{Finkelstein1981TheGA,
  title={The gramicidin a channel: A review of its permeability characteristics with special reference to the single-file aspect of transport},
  author={Alan Finkelstein and Olaf S Andersen},
  journal={The Journal of Membrane Biology},
  year={1981},
  volume={59},
  pages={155-171}
}
Gramicidin A forms univalent cation-selective channels of ≈4 Å diameter in phospholipid bilayer membranes. The transport of ions and water throughout most of the channel length is by a singlefile process; that is, cations and water molecules cannot pass each other within the channel. The implications of this single-file mode of transport for ion movement are considered. In particular, we show that there is no significant electrostatic barrier to ion movement between the energy wells at the two… CONTINUE READING

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Showing 1-10 of 66 references

Aqueous pores created in thin lipid membranes by the antibiotics nystatin, anaphotericin B, and gramicidin A: Implications for pores in plasma membranes

  • A. Finkelstein
  • In: Drugs and Transport Processes. pp. 241-250. B…
  • 1974
Highly Influential
3 Excerpts

On the position of the alkali metal cation binding sites in gramicidin channels

  • O. S. Andersen, E. W. Barrett, L. B. Weiss
  • Biophys. J. 33:63a
  • 1981
2 Excerpts

The relation between binding affinities and selectivity of a pore

  • Kohler, H.-H., K. Heckmann
  • d. Membrm~e Sci. 6:45
  • 1980
3 Excerpts

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