The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment.

@article{Laer2008TheGL,
  title={The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment.},
  author={Lut Van Laer and Els Van Eyken and Erik Frans{\'e}n and Jeroen R Huyghe and Vedat Topsakal and Jan-jaap Hendrickx and Samuli Hannula and Elina Margareetta M{\"a}ki-Torkko and Mona C. R. Jensen and Kelly Demeester and Manuela Baur and Amanda Bonaconsa and Manuela Mazzoli and Angeles Espeso and K Koen Verbruggen and Joke Huyghe and Patrick L. M. Huygen and Sylvia J. W. Kunst and Minna Manninen and Annelies Konings and Amalia N Diaz-Lacava and Michael Steffens and Thomas F. Wienker and Ilmari Pyykk{\"o} and Cor Wrj Cremers and Hannie Kremer and Ingeborg Dhooge and Dafydd Stephens and Eva Orzan and Markus H F Pfister and Michael Bille and Agnete Parving and Martti Sorri and Paul Van de Heyning and Guy Van Camp},
  journal={Human molecular genetics},
  year={2008},
  volume={17 2},
  pages={
          159-69
        }
}
Age-related hearing impairment (ARHI) is the most prevalent sensory impairment in the elderly. ARHI is a complex disease caused by an interaction between environmental and genetic factors. The contribution of various environmental factors has been relatively extensively studied. In contrast, investigations to identify the genetic risk factors have only recently been initiated. In this paper we describe the results of an association study performed on 2418 ARHI samples derived from nine centers… CONTINUE READING

Citations

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Hearing loss: mechanisms revealed by genetics and cell biology.

  • Annual review of genetics
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GRM7 variants confer susceptibility to age-related hearing impairment.

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Grainyhead-like 2 in development and cancer.

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