The gonadotropin-releasing hormone (Gnrh) gene maps to mouse chromosome 14 and identifies a homologous region on human chromosome 8

@article{Williamson1991TheGH,
  title={The gonadotropin-releasing hormone (Gnrh) gene maps to mouse chromosome 14 and identifies a homologous region on human chromosome 8},
  author={P. Williamson and Julie A Lang and Yvonne Boyd},
  journal={Somatic Cell and Molecular Genetics},
  year={1991},
  volume={17},
  pages={609-615}
}
The murine gonadotropin-releasing hormone (Gnrh) locus has been mapped to mouse chromosome 14 using a mouse × Chinese hamster somatic cell hybrid panel. The equivalent human locus, known as luteinizing hormone-releasing hormone (LHRH), has been previously mapped to 8p21-8p11.2. Four other loci mapping to the human chromosome 8 short arm have been mapped to mouse chromosome 8; two of these (PLAT, GSR) lie proximal toLHRH, and two (LPL, DEF1) lie distal toLHRH. The localization ofGnrh, the murine… 
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References

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Luteinizing hormone-releasing hormone (LHRH) is synthesized by hypothalamic neurons and affects the release of gonadotropic hormones from the anterior pituitary gland. A cDNA clone encoding the human
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TLDR
Cloned cDNAs encoding the precursor protein for gonadotropin-releasing hormone and prolactin release-inhibiting factor were isolated from libraries derived from human and rat hypothalamic mRNA and showed identity between the human placental and human hypothalamic precursor proteins.
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TLDR
The genetic and endocrinological background of a mutant strain of mouse in which the testes and ovaries fail to develop postnatally is reported, which should prove useful for studying the synthesis of hypothalamic releasing hormones as well as the role of the hypothalamic–gonadotrophin system in sexual differentiation, puberty, folliculogenesis and spermatogenesis.
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TLDR
The partially deleted gene for the common biosynthetic precursor of gonadotropin-releasing hormone and GnRH-associated peptide is transcriptionally active as revealed by in situ hybridization histochemistry of hpg hypothalamic tissue sections, but immunocytochemical analysis failed to show the presence of antigen corresponding to any part of the precursor protein.
A prolactin-inhibiting factor within the precursor for human gonadotropin-releasing hormone
The cloned complementary DNA sequence encoding the human gonadotropin-releasing hormone (GnRH) precursor protein was used to construct an expression vector for the bacterial synthesis of the 56-amino
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TLDR
A murine cDNA probe on 65 metaphase spreads in situ is used to localize the human NF68 gene to 8p21 and secondary hybridization sites at the centromeric region of chromosome 2 and the long arm of chromosome 7 are found, which are putative loci for other intermediate filaments.
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TLDR
Immunocytochemistry and in situ hybridization showed that GnRH expression was restored in the appropriate hypothalamic neurons of the transgenic hpg animals, an indication of neural-specific expression of the introduced gene.
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