The gonadotropin-releasing hormone (Gnrh) gene maps to mouse chromosome 14 and identifies a homologous region on human chromosome 8

@article{Williamson1991TheGH,
  title={The gonadotropin-releasing hormone (Gnrh) gene maps to mouse chromosome 14 and identifies a homologous region on human chromosome 8},
  author={Penny Williamson and Jill Lang and Yvonne Boyd},
  journal={Somatic Cell and Molecular Genetics},
  year={1991},
  volume={17},
  pages={609-615}
}
The murine gonadotropin-releasing hormone (Gnrh) locus has been mapped to mouse chromosome 14 using a mouse × Chinese hamster somatic cell hybrid panel. The equivalent human locus, known as luteinizing hormone-releasing hormone (LHRH), has been previously mapped to 8p21-8p11.2. Four other loci mapping to the human chromosome 8 short arm have been mapped to mouse chromosome 8; two of these (PLAT, GSR) lie proximal toLHRH, and two (LPL, DEF1) lie distal toLHRH. The localization ofGnrh, the murine… 
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References

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Human Luteinizing hormone-releasing hormone gene (LHRH) is located on short arm of chromosome 8 (region 8p11.2 → p21)
Luteinizing hormone-releasing hormone (LHRH) is synthesized by hypothalamic neurons and affects the release of gonadotropic hormones from the anterior pituitary gland. A cDNA clone encoding the human
Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat.
TLDR
Cloned cDNAs encoding the precursor protein for gonadotropin-releasing hormone and prolactin release-inhibiting factor were isolated from libraries derived from human and rat hypothalamic mRNA and showed identity between the human placental and human hypothalamic precursor proteins.
A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse.
TLDR
The partially deleted gene for the common biosynthetic precursor of gonadotropin-releasing hormone and GnRH-associated peptide is transcriptionally active as revealed by in situ hybridization histochemistry of hpg hypothalamic tissue sections, but immunocytochemical analysis failed to show the presence of antigen corresponding to any part of the precursor protein.
A prolactin-inhibiting factor within the precursor for human gonadotropin-releasing hormone
The cloned complementary DNA sequence encoding the human gonadotropin-releasing hormone (GnRH) precursor protein was used to construct an expression vector for the bacterial synthesis of the 56-amino
Localization of the 68,000-Da human neurofilament gene (NF68) using a murine cDNA probe.
TLDR
A murine cDNA probe on 65 metaphase spreads in situ is used to localize the human NF68 gene to 8p21 and secondary hybridization sites at the centromeric region of chromosome 2 and the long arm of chromosome 7 are found, which are putative loci for other intermediate filaments.
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TLDR
Immunocytochemistry and in situ hybridization showed that GnRH expression was restored in the appropriate hypothalamic neurons of the transgenic hpg animals, an indication of neural-specific expression of the introduced gene.
Genetic analysis of autoimmune type 1 diabetes mellitus in mice
TLDR
A genetic map of the mouse genome, analysed using the polymerase chain reaction, has been assembled specifically for the study and it is found that the homologue of ldd-3 may reside on human chromosomes 1 or 4 and l dd-4 on chromosome 17.
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