The gonadotropin-releasing hormone (Gnrh) gene maps to mouse chromosome 14 and identifies a homologous region on human chromosome 8

  title={The gonadotropin-releasing hormone (Gnrh) gene maps to mouse chromosome 14 and identifies a homologous region on human chromosome 8},
  author={Penny Williamson and Jill Lang and Yvonne Boyd},
  journal={Somatic Cell and Molecular Genetics},
The murine gonadotropin-releasing hormone (Gnrh) locus has been mapped to mouse chromosome 14 using a mouse × Chinese hamster somatic cell hybrid panel. The equivalent human locus, known as luteinizing hormone-releasing hormone (LHRH), has been previously mapped to 8p21-8p11.2. Four other loci mapping to the human chromosome 8 short arm have been mapped to mouse chromosome 8; two of these (PLAT, GSR) lie proximal toLHRH, and two (LPL, DEF1) lie distal toLHRH. The localization ofGnrh, the murine… 
A somatic cell hybrid panel for mouse gene mapping characterized by PCR and FISH
The mouse x Chinese hamster somatic cell hybrid panel was developed to provide a rapid method for determining chromosomal assignments in the mouse, in particular for murine for homologs of human genes, and it was confirmed that no interspecific chromosome rearrangements were present by fluorescence in situ hybridization (FISH).
A high-resolution genetic map of the nervous locus on mouse chromosome 8.
The nervous (nr) mutant mouse displays two gross recessive traits: both an exaggeration of juvenile hyperactivity and a pronounced ataxia become apparent during the third and fourth postnatal weeks.
Mouse chromosome 14
The purpose of this report is to provide a comprehensive summary of genetic, cytogenetic, mousehuman comparative, and physical mapping information and to analyze these data to develop consensus maps.
Molecular cloning of mouse canp3, the gene associated with limb-girdle muscular dystrophy 2A in human
The characterization of the mouse cDNA gene is a step towards the obtention of a canp3-deficient animal model by homologous recombination and can p3 YACs may be useful to introduce the gene by transgenesis.
Mouse homologues of human hereditary disease.
A survey of 18 mapped human disease loci and chromosome regions in which the manifestation or severity of pathological effects is thought to be the result of genomic imprinting shows that most of the homologous regions in the mouse are also associated with imprinting, especially those with homologues on human chromosomes 11p and 15q.
BMP‐1 Sublocalization on Human Chromosome 8: Molecular Anatomy and Orthopaedic Implications
Somatic-cell hybrid and molecular biology techniques were used to sublocalize the BMP-1 gene to the short arm of chromosome 8 within the 8p22-cen region, and although this locus falls outside the Langer-Giedion syndrome region, it is excluded as a candidate gene for this disorder.
Transgenics in Endocrinology
Germline Genetic Engineering Techniques in Endocrinology Albert S. Y. Chang, Michael J. Reardon, and Francesco J. DeMayo The Transgenic Mouse in Studies of Mammalian Sexual Differentiation Deanne J.
Comparative map for mice and humans
This report summarizes the status of this comparative map and provided a listing of homologous genes and anonymous loci that have been mapped in mice and humans together with references documenting homology and the chromosomal and linkage assignments.
Mouse models of human single gene disorders I: Non‐transgenic mice
  • S. Darling, C. Abbott
  • Biology, Psychology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 1992
Mouse models of human single gene disorders are described, dividing them into three categories depending on the information available; phenotypic similarities, comparative mapping and identification of the underlying genetic lesion.


Human Luteinizing hormone-releasing hormone gene (LHRH) is located on short arm of chromosome 8 (region 8p11.2 → p21)
Luteinizing hormone-releasing hormone (LHRH) is synthesized by hypothalamic neurons and affects the release of gonadotropic hormones from the anterior pituitary gland. A cDNA clone encoding the human
Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat.
Cloned cDNAs encoding the precursor protein for gonadotropin-releasing hormone and prolactin release-inhibiting factor were isolated from libraries derived from human and rat hypothalamic mRNA and showed identity between the human placental and human hypothalamic precursor proteins.
A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse.
The partially deleted gene for the common biosynthetic precursor of gonadotropin-releasing hormone and GnRH-associated peptide is transcriptionally active as revealed by in situ hybridization histochemistry of hpg hypothalamic tissue sections, but immunocytochemical analysis failed to show the presence of antigen corresponding to any part of the precursor protein.
A prolactin-inhibiting factor within the precursor for human gonadotropin-releasing hormone
The cloned complementary DNA sequence encoding the human gonadotropin-releasing hormone (GnRH) precursor protein was used to construct an expression vector for the bacterial synthesis of the 56-amino
Localization of the 68,000-Da human neurofilament gene (NF68) using a murine cDNA probe.
A murine cDNA probe on 65 metaphase spreads in situ is used to localize the human NF68 gene to 8p21 and secondary hybridization sites at the centromeric region of chromosome 2 and the long arm of chromosome 7 are found, which are putative loci for other intermediate filaments.
The hypogonadal mouse: reproductive functions restored by gene therapy.
Immunocytochemistry and in situ hybridization showed that GnRH expression was restored in the appropriate hypothalamic neurons of the transgenic hpg animals, an indication of neural-specific expression of the introduced gene.
Genetic analysis of autoimmune type 1 diabetes mellitus in mice
A genetic map of the mouse genome, analysed using the polymerase chain reaction, has been assembled specifically for the study and it is found that the homologue of ldd-3 may reside on human chromosomes 1 or 4 and l dd-4 on chromosome 17.