The golli-myelin basic protein negatively regulates signal transduction in T lymphocytes

@article{Feng2004TheGB,
  title={The golli-myelin basic protein negatively regulates signal transduction in T lymphocytes},
  author={Ji-Ming Feng and Augustine O Fernandes and Celia W. Campagnoni and Yan-hong Hu and Anthony T. Campagnoni},
  journal={Journal of Neuroimmunology},
  year={2004},
  volume={152},
  pages={57-66}
}
Protein kinase C (PKC) plays a critical role in signal transduction controlling T lymphocyte activation. Both positive and negative regulation of signal transduction is needed for proper control of T lymphocyte activation. We have found that a golli product of the myelin basic protein (MBP) gene can serve as a negative regulator of signaling pathways in the T lymphocyte, particularly the PKC pathway. Increased expression of golli BG21 in Jurkat T cells strongly inhibits anti-CD3-induced IL-2… CONTINUE READING

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