The golden anniversary of the thymus

@article{Miller2011TheGA,
  title={The golden anniversary of the thymus},
  author={Jacques F. A. P. Miller},
  journal={Nature Reviews Immunology},
  year={2011},
  volume={11},
  pages={489-495}
}
The immunological function of the thymus was first documented 50 years ago by using neonatally thymectomized mice, while studying its role in virus-induced leukaemia. Since then, an enormous wealth of reports has helped to define the importance of this primary lymphoid organ. In this article, I summarize the key advances that have led to our current knowledge of the functions of the thymus and its T cells in immunity. 
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The relevance of the thymus is discussed, followed by thymic embryological organogenesis and anatomy as well as the development and functionality of T cells, and emerging techniques that have shown promise and the challenges that lie ahead are explored. Expand
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Thymus pathology observed in the MGTX trial
The MGTX trial is the first prospective, randomized clinical trial that aims to evaluate the impact of extended transsternal thymectomy on myasthenic symptoms, prednisone requirements, and quality ofExpand
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Evidence from this laboratory, summarized below, suggests that the function of the thymus in initiating immunogenesis is not necessarily restricted to early life. Expand
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TLDR
In heavily irradiated mice, an inoculum containing a mixture of marrow and thymus cells allowed the production of more hemolysins against sheep erythrocytes than could be accounted for by summating the activities of each cell population alone. Expand
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