The glycosylation state of Kv1.2 potassium channels affects trafficking, gating, and simulated action potentials.

@article{Watanabe2007TheGS,
  title={The glycosylation state of Kv1.2 potassium channels affects trafficking, gating, and simulated action potentials.},
  author={Itaru Watanabe and Jing Zhu and Jhon Jairo Sutachan and Allan Gottschalk and Esperanza Recio-Pinto and William B. Thornhill},
  journal={Brain research},
  year={2007},
  volume={1144},
  pages={1-18}
}
We presented evidence previously that decreasing the glycosylation state of the Kv1.1 potassium channel modified its gating by a combined surface potential and a cooperative subunit interaction mechanism and these effects modified simulated action potentials. Here we continued to test the hypothesis that glycosylation affects channel function in a predictable fashion by increasing and decreasing the glycosylation state of Kv1.2 channels. Compared with Kv1.2, increasing the glycosylation state… CONTINUE READING

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