The glycolytic pathway to coronary heart disease: a hypothesis.

  title={The glycolytic pathway to coronary heart disease: a hypothesis.},
  author={Francisco Medina Leyva and Christy Wingrove and Ian F. Godsland and Jennifer C Stevenson},
  journal={Metabolism: clinical and experimental},
  volume={47 6},
Coronary heart disease (CHD) is pathogenetically linked to numerous metabolic disturbances. These are inextricably interrelated, constituting identifiable clusters or syndromes of cardiovascular risk. Prominent among these is the insulin resistance syndrome, whose components, including hyperuricemia, have all been linked to CHD pathogenesis. Many mechanisms have been put forward to account for the emergence of this syndrome, but none offer a satisfactory explanation for the involvement of… CONTINUE READING


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