The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R.

@article{Zhong2009TheGI,
  title={The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R.},
  author={Diansheng Zhong and Li Xiong and Tongrui Liu and Xiuju Liu and Xiangguo Liu and Jing Chen and S Sun and Fadlo R. Khuri and Yaping Zong and Qinghua Zhou and Wei Zhou},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 35},
  pages={23225-33}
}
Recent molecular studies indicate that aerobic glycolysis plays an important role in tumorigenesis and is a valid target for cancer therapy. Although 2-deoxyglucose (2-DG) is well characterized as a glycolytic inhibitor, we recently discovered that it activates a prosurvival oncoprotein, AKT, through PI3K. In this study, we discovered that 2-DG treatments disrupted the binding between insulin-like growth factor 1 (IGF-1) and IGF-binding protein 3 (IGFBP3) so that the free form of IGF-1 could be… CONTINUE READING

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BIOLOGICAL CHEMISTRY 23233 by gest on M arch 3, 2015 hp://w w w .jb.org/ D

  • P. J. Roberts, C. J. Der
  • Oncogene
  • 2007
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