The glycine transport inhibitor sarcosine is an NMDA receptor co-agonist that differs from glycine.

@article{Zhang2009TheGT,
  title={The glycine transport inhibitor sarcosine is an NMDA receptor co-agonist that differs from glycine.},
  author={Hai Xia Zhang and Krzysztof L. Hyrc and Liu Lin Thio},
  journal={The Journal of physiology},
  year={2009},
  volume={587 Pt 13},
  pages={
          3207-20
        }
}
Sarcosine is an amino acid involved in one-carbon metabolism and a promising therapy for schizophrenia because it enhances NMDA receptor (NMDAR) function by inhibiting glycine uptake. The structural similarity between sarcosine and glycine led us to hypothesize that sarcosine is also an agonist like glycine. We examined this possibility using whole-cell recordings from cultured embryonic mouse hippocampal neurons. We found that sarcosine is an NMDAR co-agonist at the glycine binding site… CONTINUE READING
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