The glutathione system of peroxide detoxification is less efficient in neurons than in astroglial cells.

@article{Dringen1999TheGS,
  title={The glutathione system of peroxide detoxification is less efficient in neurons than in astroglial cells.},
  author={Ralf Dringen and Lucinda Kussmaul and Jan Mirko Gutterer and Johannes Hirrlinger and Bernd Hamprecht},
  journal={Journal of neurochemistry},
  year={1999},
  volume={72 6},
  pages={2523-30}
}
The ability of neurons to detoxify exogenously applied peroxides was analyzed using neuron-rich primary cultures derived from embryonic rat brain. Incubation of neurons with H2O2 at an initial concentration of 100 microM (300 nmol/3 ml) led to a decrease in the concentration of the peroxide, which depended strongly on the seeding density of the neurons. When 3 x 10(6) viable cells were seeded per dish, the half-time for the clearance by neurons of H2O2 from the incubation buffer was 15.1 min… CONTINUE READING
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