The glutathione S-transferases: influence of polymorphism on cancer susceptibility.

  title={The glutathione S-transferases: influence of polymorphism on cancer susceptibility.},
  author={Richard C. Strange and Anthony A Fryer},
  journal={IARC scientific publications},
The glutathione S-transferase supergene family is an important part of cellular enzymic defence against endogenous and exogenous chemicals, many of which have a carcinogenic potential. However, while a wide variety of chemicals can act as substrates for different members of the supergene family, the precise function of these enzymes remains unclear. The supergene family comprises several gene families that include polymorphic loci, prompting the hypothesis that allelic variants associated with… CONTINUE READING
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