The glutathione S-transferase M1 (GSTM1) null genotype and benzidine-associated bladder cancer, urine mutagenicity, and exfoliated urothelial cell DNA adducts.

@article{Rothman1996TheGS,
  title={The glutathione S-transferase M1 (GSTM1) null genotype and benzidine-associated bladder cancer, urine mutagenicity, and exfoliated urothelial cell DNA adducts.},
  author={Nat Rothman and Richard B Hayes and Terry V. Zenser and David M. DeMarini and Wenxiang Bi and A Hirvonen and Glenn Talaska and Vijai K Bhatnagar and Neil E. Caporaso and Lance R Brooks and Vijaya M. Lakshmi and Peiying Feng and Suresh Kumar Kashyap and Xin You and B T Eischen and Rekha Kashyap and Mary Lee Shelton and Fong Fu Hsu and Matthias J{\"a}ger and Dinesh J Parikh and Bernard B. Davis and Song-nian Yin and Douglas A. Bell},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={1996},
  volume={5 12},
  pages={979-83}
}
Multiple studies in the general population have suggested that subjects with the glutathione S-transferase M1 (GSTM1)-null genotype, who lack functional GSTM1, are at higher risk for bladder cancer. To evaluate the impact of the GSTM1-null genotype on bladder cancer caused by occupational exposure to benzidine and to determine its influence on benzidine metabolism, we carried out three complementary investigations: a case-control study of bladder cancer among workers previously exposed to… CONTINUE READING