The glutamine commute: lost in the tube?

  title={The glutamine commute: lost in the tube?},
  author={Fiorenzo Conti and Marcello Melone},
  journal={Neurochemistry international},
  volume={48 6-7},
The "glutamate-glutamine" cycle appears to have an important, albeit not exclusive role, in the recycling of glutamate (Glu) between neurons and astrocytes. Recent studies show that the efflux of glutamine (Gln) from astrocytes is mediated by SNAT3 (formerly SN1), a system N amino acid transporter localized to perisynaptic astrocytes, whereas its influx into neurons is thought to be mediated by transporters of the system A family, specifically SNAT1 and SNAT2. However, the results of our… CONTINUE READING
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