The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268).

@article{Coffman1998TheGO,
  title={The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268).},
  author={Birgit L Coffman and Clare D King and Gladys R Rios and Thomas R. Tephly},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1998},
  volume={26 1},
  pages={73-7}
}
UGT2B7 has been cloned and expressed previously in COS cells and HK293 cells. Two forms have been identified: one with a tyrosine and one with a histidine at position 268. UGT2B7 has been shown to catalyze NSAIDs, catechol estrogens, and morphine-3- and -6-glucuronidation. cDNAs for UGT2B7Y268 and H268 were cloned and stably expressed in HK 293 cells. Studies were designed to test each form for reactivity toward a number of opioid compounds, xenobiotics such as menthol, oxazepam, and… CONTINUE READING
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