The glucuronidation of morphine by dog liver microsomes: identification of morphine-6-O-glucuronide.

  title={The glucuronidation of morphine by dog liver microsomes: identification of morphine-6-O-glucuronide.},
  author={Clare D King and Brandon Finley and Ronald B. Franklin},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={28 6},
Canines are used extensively in the pharmaceutical industry for the preclinical screening of novel therapeutics, yet comparatively little is known about the phase 2 metabolism in this species. In humans, morphine is known to undergo extensive metabolism by glucuronidation, and the UDP-glucuronosyltransferase isoform, which catalyzes the formation of morphine-3-O-glucuronide and morphine-6-O-glucuronide is UGT2B7. This study was designed to investigate the glucuronidation of morphine using dog… CONTINUE READING


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